Preview Text Soundararajan_Enhancing the Bioavailability of BCS ClassIV drugs using polymeric nanoparticles.pdf Abstract Hydrophobic drugs that are P-gp substrates (BCS Class IV) such as paclitaxel, CUDC-101 etc. Pose a serious challenge for oral drug delivery. Polymeric amphiphiles such as N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ) are capable of enhancing the bioavailability of hydrophobic drugs by forming nanoparticles. The general hypothesis is that the physicochemical properties of the polymer will affect the colloidal stability, encapsulation efficiency and absorption of hydrophobic drugs. The main aims of the project are as follows: a) to examine the feasibility of using GCPQ with different characteristics, for the oral and subcutaneous delivery of CUDC-101 and b) to examine the effect of N-(2-phenoxyacetamide)-6-O-glycolchitosan (GCPh) on the P-gp efflux of paclitaxel. GCPh, a new polymeric amphiphile was synthesized by conjugating glycol chitosan to phenoxy acetic acid. Paclitaxel and CUDC-101 were encapsulated with GCPh and GCPQ of different molecular weights and hydrophobicity.
The in vivo oral drug absorption profile for paclitaxel-GCPh nanoparticles and paclitaxel-Taxol® nanoparticles were determined in mice with and without verapamil, a P-gp inhibitor. In another study, the oral and subcutaneous drug absorption profile for CUDC-101 – GCPQ nanoparticles were conducted in mice and rat models respectively. Results indicated that GCPh improved the oral absorption of paclitaxel by improving the dissolution and promoting particle uptake through enterocytes.
Bc Class 4 Do You Have To Check Oil
Bcs Class 1 Drugs
Developed for BCS Class 1 and BCS Class 3 APIs. This is to be expected because the compounds are highly soluble in water or gastrointestinal pH media. However, it is noted that there are a few BCS class 2 and class 4 compounds that are formulated as oral solutions or syrups. Dec 22, 2017 FDA has issued a final guidance entitled Waiver of In-vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System. Ketoprofen, a widely prescribed analgesic drug which belongs to BCS class II and exhibit low and variable oral bioavailability due to its poor aqueous solubility. To enhance the solubility and dissolution rate of poorly water soluble drug Ketoprofen, Self-micro emulsifying drug delivery system (SMEDDS) was developed and evaluated. BCS class 4 drugs are the drugs having low solubility and permeability according to classification system given by Amidon et. These drugs are formulated such that it is made more permeable and more soluble with help of different formulation techniques. Solid dispersion is the technique primarily used.